Author + information
- Zahra Meyghani,
- Hooman Bakhshi,
- Bharath Ambale Venkatesh,
- Yoshiaki Ohyama,
- Colin O. Wu,
- Matthew Budoff,
- Christina L. Wassel,
- Michael Criqui,
- David Bluemke and
- Joao Lima
Introduction: Peripheral artery disease (PAD) is associated with mortality and high economic burden on health care system. Since PAD remains asymptomatic until advanced stages, it is important to identify individuals at risk. In this study we investigated the association between coronary artery calcium (CAC) and incident PAD.
Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective, population-based study consisting of 6814 men and women from four ethnic groups. Participants were free of clinical cardiovascular disease at enrollment. We included participants who had the CAC score measured at baseline exam (2000- 2002)and had an ankle brachial index (ABI) at follow up exam (2010- 2011). We excluded participants with baseline ABI ≤0.9 or >1.4 or a follow up ABI>1.4. Incident PAD was defined as a follow up ABI≤0.9. Natural logarithm of CAC score was used. Multivariable logistic regression models were used to investigate the association of CAC with incident PAD.
Results: The mean (SD) age was 59.9 (9.4) years and 53.4% were female. During a median (IQR) of 9.4 (9.1-9.7) years of follow up, 169 out of 4257 participants developed PAD. Participants with baseline CAC>0 showed higher incidence of PAD (112/1729) in comparison with those with no CAC(57/2359). One unit increase in log(CAC+1) was associated with 1.17 fold higher odds of incident PAD independent of traditional cardiovascular risk factors.
Conclusions: Baseline CAC predicts incident PAD in a multi-ethnic population.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Novel Risk Measures in Arterial Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167-358
- 2017 American College of Cardiology Foundation