Author + information
- Harun Kilic,
- Yusuf Can,
- Murat Aksoy,
- Ersan Tatli,
- Tarik Agac,
- Mehmet Akif Cakar,
- Mustafa Gökhan Vural,
- Ramazan Akdemir and
- Gunduz Huseyin
Background: Lactate is produced by most tissues in the human body, with the highest level of production found in muscle. Typical intermittent claudication could theoretically be attributed to ischemia induced by an oxygen demand and supply imbalance. Under anaerobic conditions, lactate is an end product of glycolysis. The aim of the present study is to compare the lactate levels of ischemic limb before and after intervention.
Methods: Thirty patients, 26 men and 4 women, median age 62,62 years (range 46-79 years), suffering intermittent claudication were included. Seven patients have subclavien stenosis and 23 patients have lower extremity stenosis. Lactate samples were obtained from the ischemic limb drainage vein, either femoral or brachial vein under resting conditions before and after intervention.
Results: After revascularization; lactate levels decreased significantly (1,67 vs. 1,57 mmol/L, p=0,01), blood pH increased (7,35 vs7,38, p=0.09), blood pCO2 decreased significantly (47,38 vs. 42,34 mmHg, p=0.02). Lactate decrease was more prominent in subclavien stenosis revascularizations (1.95 vs. 1.25 mmol/L, p<0.001).
Conclusions: Increased limb tissue perfusion decreased limb hypercarbia, leading to improvement of blood pH. Decrease in lactate levels was observed after successful revascularization which was more significant in subclavien stenosis interestingly. This study also shows that there is ongoing ischemia at the limb under resting conditions in which the patient is asymptomatic.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Venous Investigation: The Dark Side
Abstract Category: 39. Vascular Medicine: Endovascular Therapy
Presentation Number: 1168-362
- 2017 American College of Cardiology Foundation