Author + information
- Koutagiar Peter Iosifa,b,
- Konstantinos Toutouzasa,b,
- Georgios Benetosa,b,
- Nikoletta Pianoua,b,
- Ioannis Skoumasa,b,
- Alexandros Georgakopoulosa,b,
- Spyridon Galanakosa,b,
- Pavlos Kafourisa,b,
- Angeliki Rigatoua,b,
- Andreas Synetosa,b,
- George Spyroua,b,
- Eleftherios Tsiamisa,b,
- Michael Petersa,b,
- Constantinos Anagnostopoulosa,b and
- Dimitris Tousoulisa,b
Background: Familial combined hyperlipidemia (FCH) is characterized by increased prevalence of non-alcoholic fatty liver disease, leading to a pro-atherothrombotic state and systemic inflammatory activation. No data exist about the impact of the heterozygous familial hypercholesterolemia (heFH), another type of familial dyslipidemia, on liver function. The aim of this study was to investigate the effect of FCH and heFH on inflammation of the arterial wall and liver using 18F fluorodeoxyglycose Positron Emission Tomography (FDG-PET).
Methods: Twenty eight patients (9 female) with FCH (n=14) or heFH (n=14) free of statin therapy, and 14 non dyslipidemic patients (7 female) of similar age were included. Target to background ratio (TBRCAR derived from the ratio meanSUVmax/blood pool mean SUV and TBRLIVER from SUVmax/blood pool mean SUV) was used for the quantification of FDG uptake within carotid wall and hepatic tissue, respectively. Lipid profile was obtained in all dyslipidemics.
Results: FCH patients had higher TBRCAR values compared to hFH and controls (2.46±0.36 versus 2.06±0.36 versus 1.81±0.26, respectively, p<0.001). This difference remained significant even after adjustment for gender, age, hypertension and smoking (beta=0.28, p<0.001). Regarding liver's measurements, FCH patients exhibited higher TBRLIVER values compared to heFH patients and controls (3.25±0.46 versus 2.65±0.33 versus 2.41±0.27, p<0.001). This difference remained significant even after adjustment for gender, age, hypertension and smoking (beta=0.39, p<0.001). Performing comparisons between groups, FCH patients showed higher TBRLIVER values compared to heFH (p<0.001) and to controls (p<0.001). Finally, there was a positive correlation between TBRCAR and TBRLIVER(R=0.439, p=0.008).
Conclusions: Subclinical arterial inflammation and hepatic FDG uptake are higher in FCH compared to heFH and controls. In a group of individuals with or without dyslipidemia carotid wall inflammation was associated with liver FDG uptake.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Cutting Edge Vascular Medicine
Abstract Category: 38. Vascular Medicine: Basic
Presentation Number: 1205-361
- 2017 American College of Cardiology Foundation