Author + information
- Jens Sundboll,
- Erzsébet Horváth-Puhó,
- Kasper Adelborg and
- Henrik Toft Sorensen
Background: The association between deep venous thrombosis in the lower limb and cancer is well known. However, whether upper-extremity deep venous thrombosis (UEDVT – encompassing thrombosis of the axillary, subclavian, or brachial veins), is a marker of occult cancer is poorly understood.
Methods: Using nationwide population-based medical registries, we identified all patients with first-time UEDVT between 2001–2013. Cancer outcomes of the study cohort were ascertained using data from the Danish Cancer Registry. We computed standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) calculated as the observed number of cancers relative to the expected based on national incidence rates by sex, age, and calendar year.
Results: Among 248 patients with UEDVT, we observed 30 cancers. The risk of any cancer was 6.5% (95% CI: 4.9%–8.1%) after 6 months, increasing to 12.1% (95% CI: 10.0%–14.2%) after 13 years of follow-up. During the first 6 months of follow-up, the SIR of any cancer was 12.32 (95% CI: 7.04–20.02). The SIR remained elevated during 6–12 months (3.70, 95% CI: 1.01–9.46), but approximated unity thereafter (0.93, 95% CI: 0.44–1.71). The overall results were driven by an elevated risk of lung cancer (risk after 6 months=1.6%, 95% CI: 0.8%–2.4%; 0–6 month SIR=33.15, 95% CI: 9.02-84.86).
Conclusions: A diagnosis of UEDVT is a strong clinical marker of prevalent cancer. The clinical utility of search for an occult cancer in patients presenting with UEDVT is unknown.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Venous Disease
Abstract Category: 41. Vascular Medicine: Venous Disease
Presentation Number: 1256-361
- 2017 American College of Cardiology Foundation