Author + information
- Heriberte-Ontiveros Mercadoa,b,
- Jose Francisco Munoz-Vallea,b,
- Lorena Valerdi Contrerasa,b,
- Jorge Ramon Padilla-Gutierreza,b,
- Jorge Eduardo Hernandez-del-Rioa,b,
- Miriam Sagrario Alvarez-Villanuevaa,b,
- Emmanuel Valdes-Alvaradoa,b,
- Sarai Citlalic Rodriguez-Reyesa,b and
- Yeminia Vallea,b
Background: The Macrophage Migration Inhibitory Factor (MIF) is a cytokine mediator in the formation of intra-coronary atheroma plaques and in the heart's inflammatory and remodeling responses after Acute Coronary Syndromes (ACS). The aim was to investigate if the serum concentration of MIF or if the -794 (CATT)5-8 polymorphism in MIF gene could be related to ACS incidence in patients with type 2 Diabetes Mellitus (DM2) and how this modify the responses of the heart after an ACS.
Methods: A case/control descriptive study including 80 subjects classified in four groups: 1) healthy controls, 2) patients with DM2, 3) patients with ACS without DM2 and 4) patients with DM2 and ACS. All subjects had a measure of lipid profile and HbA1C. MIF serum levels were measured in all subjects by enzyme/linked immunosorbent assay. The (CATT)5-8 polymorphism was analyzed by Polymerase Chain Reaction. Ejection fraction, mass and volume of the left ventricle were obtained by echocardiography in groups 3 and 4.
Results: By group of study MIF levels medians were as follows: 1) 4.86, 2) 6.04, 3) 4.43 and 4) 4,44 ng/ml. With a significant difference among groups 2 and 4 (p=0.003). MIF levels were not related to the percentage of HbA1C, the lipid profile or the echocardiography variables. We divided the population by presence or absence of the allele 5 of the (-794 CATT)5-8 polymorphism; in healthy subjects, allele 5 carriers have higher levels of MIF (Median 5.5 vs 3.5 ng/ml p=004). In group 4 the presence of the allele 5 was related to a minor left ventricle index volume when compared to those with any other combination of alleles (51.3 vs 112ml p<0.025).
Conclusions: In patients with ACS, the levels of MIF were not as high as previously reported. The highest concentration of MIF was in the group 3 which could be related to the administration of drugs for secondary prophylaxis in patients with ACS. In the small group of subjects with DM2 and ACS the index volume of the left ventricle was lesser in allele 5 carriers, whether this prevents the increase of volume needs to be ascertained with a larger sample. Clinical implications: MIF could act as a marker for myocardial damage and a therapeutic target to modify the prognostic and heart remodeling after a SCA.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: ACC International Conferences Best Posters
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1050-453
- 2017 American College of Cardiology Foundation