Author + information
- Uwe Zeymer,
- Xavier Rossello,
- Stuart J. Pocock,
- Frans Van de Werf,
- Nicolas Danchin,
- Lieven Annemans,
- Jesús Medina and
- Héctor Bueno
Background: Patients discharged after an acute coronary syndrome (ACS) have substantial risk of recurrent ischemic events (MACCE = death, MI, stroke).
Methods: EPICOR (NCT01171404) is a prospective, international, real-world cohort study of consecutive patients hospitalized for an ACS within 24 hours of symptom onset, who survived to discharge. 10,567 patients enrolled from 555 hospitals in 20 countries in Europe and Latin America were followed for 2 years. 4,943 were admitted with ST-segment elevation (STE) MI and 5,624 with non-STE-ACS. We studied potential baseline predictors of MACCE in the first and second year post-discharge using multivariable Cox proportional hazard models.
Results: The rates per 100 person-years at risk within and after the first year are:
Older age, lack of coronary revascularization, creatinine, hemoglobin, previous cardiac disease, previous chronic obstructive pulmonary disease, glucose, male gender and region were risk factors for MACCE during the 1st- and 2nd-follow up year but ejection fraction, quality of life, low body mass index <20 kg/m2, in-hospital cardiac complications and Killip class lost predictive power after the first year.
Conclusions: In our cohort mortality is higher in the first year after ACS, while rates of MI and stroke did not change. Some predictors of early ischemic events after an ACS lose their predictive power over time.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Acute Coronary Syndromes, Diagnosis, Management and Outcomes
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1253-330
- 2017 American College of Cardiology Foundation