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Background: Environmental pollution is a risk factor for cardiovascular disease, and non-occupational lead exposure is associated with cardiovascular mortality in the US population. Although the evidence for metals other than lead and cadmium is less robust, overall toxic metal burden may constitute a cardiovascular risk. There is, however, no known biomarker for overall toxic metal exposure.
Methods: Twenty-six patients (post-MI, age >50 years, creatinine ≤ 2.0 mg/dL) without known occupational toxic metal exposure participated. 19 toxic metals normalized to urinary creatinine concentration were measured in overnight urine collections. Total urinary metal level was calculated as the sum of all toxic metals detected.
Results: Mean age was 65 years (51 to 81 years). All patients were male. Mean (SD) serum creatinine was 0.9 (0.3) mg/dL. Toxic metals were detected in all patients. Lead accounted for nearly 2% of the total urinary metal load. In an age-adjusted model, urine lead was a predictor of urinary Al (r2=0.29; P=0.002), Cd (r2=0.34; P<0.001), Ba (r2=0.35; P<0.001), Hg (r2=0.20; P<0.01) and Ni (r2=0.22; P<0.01). The table shows toxic metal levels in the lowest vs. the upper two lead quartiles.
Conclusions: In patients with coronary disease, urinary lead correlated with levels of other toxic metals and with the total level of urinary toxic metal. Urinary lead may serve as a surrogate biomarker of non-occupational environmental exposure to several toxic metals in patients with coronary artery disease.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Insights Into Ischemic Heart Disease: Stable to Erosive Plaques
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1295-297
- 2017 American College of Cardiology Foundation