Author + information
- Carlos A. Gongoraa,b,
- Seyedhamed Hosseinidehkordia,b,
- Alejandro Lemora,b,
- Chirag Bavishia,b,
- Abel Casso Domingueza,b,
- Alejandro Zulbarana,b,
- Karomibal Mejiaa,b,
- Farit Gholitabara,b,
- Shawn Leea,b,
- Shilpkumar Aroraa,b,
- Hafeez Hassana,b and
- Edgar Arguliana,b
Background: Beta-blocker use is considered contraindicated in patients with cocaine-induced chest pain but the evidence base for this recommendation is scarce. We aimed at investigating the clinical outcomes in patients treated with beta blockers that presented with cocaine-induced chest pain.
Methods: Electronic databases were systematically searched to identify manuscripts addressing cocaine associated chest pain treated with or without beta blockers. We examined the following end-points: all-cause mortality and myocardial infarction/myocardial necrosis (MI). Pooled risk ratios (RR) and their 95% confidence intervals (CI) were calculated for all outcomes using a random-effect model.
Results: Five studies with a total of 1,447 patients were included. This study showed no difference for myocardial infarction (RR 1.08, 95% CI 0.61, 1.91, p=0.79) or all-cause mortality (RR 0.75, 95% CI 0.46, 1.24, p=0.27) in patients treated with or without beta blockers. Heterogeneity was low to moderate, Figure 1.
Conclusions: Beta blockers do not appear to be associated with adverse clinical outcomes in patient with chest pain and cocaine use.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Unusual Presentations of ACS
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1297-324
- 2017 American College of Cardiology Foundation