Author + information
- Francois Schiele,
- Jean Ferrières,
- Etienne Puymirat,
- Nicolas Meneveau,
- Tabassome Simon and
- Nicolas Danchin
Background: We investigated rates of prescription and predictors of statin use at discharge and 1 year after AMI, and the association with long term mortality in 7839 pts included in the French FAST-MI 2005 and 2010 registries.
Methods: Statin prescription was recorded at discharge and 1 year in all pts admitted for AMI in 76% of French hospitals over a 1-month period. Clinical follow-up for all-cause mortality was available in 7699 (98%) pts.
Results: 1270/7839(16.5%) pts were discharged without, and 6422(82%) with statins, including 2913(45%) at high intensity. Among pts discharged without statins, 1014 were never treated with statins and previous statin therapy was stopped in 256 (3.3%). At 1 year, among pts without statins at discharge, 343(43%) were treated with statins; predictors of re-starting statins were female gender, NSTEMI presentation, revascularization with PCI, statins before index admission and high level of LDL-C. Multivariate Cox analysis showed that 3 year mortality was higher in those who never had statins (HR=5.88, 95%CI 3.31; 50.0), and in those who had discontinued statins prescribed at discharge (HR=3.15, 95%CI 1.92; 5.05). Conversely, pts discharged without statins but who were taking statins at one year had no excess risk of mortality (figure).
Conclusions: Whatever the prescription of statins at discharge, statin use at 1 year was associated with 3-year survival in MI pts. In pts without statins at discharge, re-starting statins was associated with lower long term mortality.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Unusual Presentations of ACS
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1297-331
- 2017 American College of Cardiology Foundation