Author + information
- Kazuhiro Fujiyoshi,
- Yoshiyasu Minami,
- Ryota Kakizaki,
- Teruyoshi Nemoto,
- Sayaka Namba,
- Takuya Hashimoto,
- Kentaro Meguro,
- Takao Shimohama,
- Minako Yamaoka-Tojo,
- Taiki Tojo and
- Junya Ako
Background: Lower level of eicosapentaenoic acid to arachidonic acid ratio (EPA/AA) is associated with higher incidence of cardiovascular events. Recent studies have demonstrated that intraplaque cholesterol crystal (CC) plays an important role for plaque destabilization. However, the correlation between EPA/AA and CC has not been evaluated so far.
Purpose: To clarify the correlation between serum EPA/AA level and the prevalence of CC.
Methods: Consecutive 200 patients with stable angina pectoris who underwent optical coherence tomography (OCT) imaging of culprit lesion were included. CC was defined as a thin, linear region of high signal intensity within the lipid plaque on OCT image.
Results: A total 65 patients (32.5%) had CC. The rate of smoker and diabetes in patients with CC was significantly higher than those without CC. EPA/AA was significantly lower in patients with CC than those without CC (0.33 ± 0.04 vs. 0.60 ± 0.03, p<0.001) (Figure). Multivariate analysis demonstrated that EPA/AA was the independent predictor of the presence of CC (OR 0.76, CI 1.15 −1.52, per 0.1 increase, p<0.001), whereas smoker (OR 1.66, CI 0.84 – 3.30, p=0.141) and diabetes (OR 1.71, CI 0.88 – 3.31, p=0.109) was not significant as an independent predictor.
Conclusions: Lower EPA/AA level was associated with higher prevalence of CC. This result may partly explain the higher incidence of cardiovascular events in patients with lower EPA/AA level.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Unusual Presentations of ACS
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1297-342
- 2017 American College of Cardiology Foundation