Author + information
- Hideki Wadaa,b,
- Tomotaka Dohia,b,
- Katsumi Miyauchia,b,
- Shuta Tsuboia,b,
- Manabu Ogitaa,b,
- Takatoshi Kasaia,b,
- Satoru Suwaa,b and
- Hiroyuki Daidaa,b
Background: Inflammation plays an important role in the progression of atherosclerosis. Furthermore, malnutrition has been reported to be closely linked inflammation and atherosclerosis. We investigated the effect of combined serum albumin and C-reactive protein (CRP) on clinical outcomes after percutaneous coronary intervention (PCI).
Methods: We studied 2,164 all-comer patients with CAD who underwent their first PCI and had data available for pre-procedural serum albumin and hs-CRP at Juntendo University between 2000 and 2011. Patients were assigned to four groups according to median serum albumin and CRP levels. We evaluated the incidence of major adverse cardiac events (MACE) including all-cause death and acute coronary syndrome (ACS).
Results: Patients in low albumin and high CRP group were likely to be older and higher prevalence of chronic kidney disease, ACS and hypertension. During a median follow-up period of 7.5 years, Kaplan-Meier curves showed the rate of MACE was significantly differed among the groups (log-rank p<0.0001, Figure). After adjustment for established cardiovascular risk factors, low albumin with high CRP levels were associated with adverse cardiac events (HR 2.17, 95%CI 1.56-2.95, p<0.0001, reference as high albumin / low CRP group).
Conclusions: Low serum albumin with high CRP levels is independently associated with long-term outcomes in patients after PCI.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Unusual Presentations of ACS
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1297-348
- 2017 American College of Cardiology Foundation