Author + information
- Sungsoo Kima,b,
- Kim Hyun Kuka,b,
- Hyung Wook Parka,b,
- Myung Ho Jeonga,b,
- Dong Goo Kanga,b,
- Seung Uk Leea,b,
- Sang Ki Choa,b,
- Cho Jae Younga,b,
- Min Chul Kima,b,
- Ki Hong Leea,b,
- Namsik Yoona,b and
- Jeong-Gwan Choa,b
Background: Ventricular arrhythmias are important causes for sudden cardiac death in acute myocardial infarction (AMI). Recently, a beneficial effect of renal denervation (RDN) has been seen in patient with ventricular electrical storm. However, the antiarrhythmic effect of RDN after AMI remains unclear.
Methods: Twenty swine were randomized to group 1 (RDN, n=10), or group 2 (Sham, n=10). After general anesthesia, implantable loop recorder (ILR) was implanted for the recording of arrhythmic events. AMI was induced by occlusion of the left anterior descending artery. After induction of AMI, bilateral RDN was achieved by ablation at six to eight sites in each renal artery in the RDN group. Radiofrequency current (6-8W, 120s) was delivered to the sites. One weeks later, follow up coronary angiogram and renal angiogram was performed. Animals were sacrificed within their heart and kidney subsequently retrieved and ILR was analyzed.
Results: Periprocedural VT/VF after AMI was not different in the two groups after AMI. (8 VT/VF in RDN group vs. 6 VT/VF in sham group, P=0.628). However, RDN decreased mortality (arrhythmic death) for follow up period. (1 arrhythmic death in RDN vs. 5 arrhythmic deaths in sham, P=0.041).
Conclusions: Our data show RDN reduced the occurrence of arrhythmic death after AMI. These findings suggest RDN may become a new therapeutic option in a AMI patient.
Room 146 A
Saturday, March 18, 2017, 9:17 a.m.-9:27 a.m.
Session Title: Highlighted Original Research: Arrhythmias and Clinical EP and the Year in Review
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 901-14
- 2017 American College of Cardiology Foundation