Author + information
- Samuel Z. Goldhaber,
- A. John Camm,
- Gabriele Accetta,
- Jean-Pierre Bassand,
- David Fitzmaurice,
- Shinya Goto,
- Sylvia Haas,
- Werner Hacke,
- Gloria Kayani,
- Frank Misselwitz,
- Lorenzo Mantovani,
- Alexander Turpie,
- Martin van Eickels,
- Freek Verheugt and
- Ajay Kakkar
Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is a non-interventional study which, like Framingham Heart Study, provides a record of early events from the time of diagnosis of nonvalvular atrial fibrillation (AF). Patients were enrolled in GARFIELD-AF an average of 2 weeks (and not more than 6 weeks) after the diagnosis of nonvalvular AF.
Methods: This analysis of 28,628 patients recruited between Mar-2010 and Oct-2014 investigates the causes of death in relation to the time of death after the diagnosis of AF.
Results: All-cause mortality was 60% higher in the first month after diagnosis of AF (rate ratio: 1.6 95% confidence interval [CI] 1.4 to 1.9) compared with the average all-cause mortality rate of 3.8 per 100 person-years over the first 24 months of follow-up. Excess mortality (rate ratio [95% CI]) over the first month for patients with and without a prior history of acute coronary syndrome (ACS) was 2.1 (1.4 to 2.9) and 1.5 (1.3 to 1.8), for patients with and without prior stroke 2.3 (1.5 to 3.2) and 1.5 (1.3 to 1.8), and for patients <65 yrs 2.2 (1.4 to 3.2) or >85 yrs 1.5 (1.1 to 2.1). Cardiovascular events (notably heart failure) were the most important cause of early deaths (Fig.1).
Conclusions: Factors such as prior ACS and stroke contribute to early excess mortality and point to the importance of comprehensive care for patients with AF.
Moderated Poster Contributions
Arrhythmias and Clinical EP Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 11:00 a.m.-11:10 a.m.
Session Title: Atrial Fibrillation, Anticoagulation and Novel Device Therapies
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1134M-11
- 2017 American College of Cardiology Foundation