Author + information
- Aashay Patel,
- Dixitha Anugula,
- Arun Kanmanthareddy,
- Prakrity Urja,
- Toufik Mahfood Haddad and
- Venkata Alla
Background: Premature Atrial Complexes (PACs) are frequently observed on routine ECG's and holter monitors. However, their prognostic significance in healthy individuals is not fully elucidated. We performed this Meta-Analysis to assess the impact of PACs on cardiovascular outcomes.
Methods: MEDLINE, EBSCO and Google Scholar databases were searched for relevant studies. Studies generally defined frequent PACs as occurring ≥1 time during a standard ECG recording or ≥30 times over a 1-hour recording or any episodes with runs of ≥20 PACs. We calculated risk ratio (RR) and 95% Confidence interval (CI) using random-effects models for the outcomes of Atrial Fibrillation (AF), stroke, All-cause mortality and cardiovascular mortality in selected sample. STATA 13.0 software was used to perform statistical analysis.
Results: A total of six studies with 84,870 participants were included. The overall RR for new onset AF in participants with frequent PACs vs those without frequent PACs during the follow up period was 3.38 (95% CI 1.63-7.01). The risk of stroke (RR 2.88, 95% CI: 1.71-4.84), all-cause mortality (RR 2.23, 95% CI: 1.93-2.59) and cardiovascular mortality (RR 3.07,95% CI: 2.63-3.59) were all significantly higher in the group with PACs.
Conclusions: The results of our meta-analysis suggest that frequent PACs are associated with increased risk of AF, stroke, all-cause and cardiovascular mortality. Further studies are needed to determine whether PACs suppression can decrease adverse outcomes.
Moderated Poster Contributions
Arrhythmias and Clinical EP Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-9:55 a.m.
Session Title: Arrhythmias and Heart Failure
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1305M-03
- 2017 American College of Cardiology Foundation