Author + information
- Anoop Ninan Koshy,
- Jithin Sajeev,
- Kevin Rajakariar,
- Esther Briganti,
- Peter Andrew,
- Mark Zureik,
- Edward Quine,
- Shane Parfrey,
- Prasanna Venkataraman,
- Louise Roberts and
- Andrew W. Teh
Background: High atrial ectopic burden has been associated with an increased risk of developing atrial fibrillation (AF) and an increased risk of ischemic stroke beyond manifest AF.
Methods: A single centre case-control study was performed among patients with an ischemic stroke, who had subsequent holter monitoring between May 2011-2015. Premature atrial complex (PAC) burden and atrial runs ≥ 3 beats were compared to a group of age and sex matched controls without prior stroke at a 2:1 ratio.
Results: 2,804 patients that presented with an ischemic stroke were included in the primary analysis, of which 461 stroke patients and 250 controls that underwent 24-hour monitoring were included. The groups were well matched for age, risk factors and medication use at time of the index event. There was a statistically significant higher mean PAC burden (426 vs 105, p<0.001) and higher number of atrial runs (8 vs 2, p= 0.002) in the stroke patients, although no significant difference was noted in the longest atrial runs (7 vs 6; p=0.40) between the groups(Table). A CHADS2 VASC ≥ 3 was also associated with a higher mean atrial ectopic burden (323 vs 58, p<0.001).
Conclusions: Ischemic stroke patients have an increased PAC burden and atrial runs compared with age-matched controls. A higher traditional risk factor profile is associated with a higher mean atrial ectopic burden. This supports the increasing body of evidence that links atrial ectopy as a clinical measurement that may contribute in the pathogenesis of cryptogenic stroke.
Moderated Poster Contributions
Arrhythmias and Clinical EP Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 1:00 p.m.-1:10 p.m.
Session Title: Novel Arrhythmia Diagnostics, Therapeutics, and “Wearables”
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1315M-07
- 2017 American College of Cardiology Foundation