Author + information
- Muhammad Soubhi Azzouza,b,
- Amer Kadria,b,
- Nawfal Al-Khafajia,b,
- Toufik Mahfood Haddada,b,
- Michael Del Corea,b,
- Michael Whitea,b and
- Venkata Allaa,b
Background: Multiple randomized controlled trials have demonstrated the favorable impact of Therapeutic Hypothermia (TH) in out of hospital cardiac arrest. The benefit of TH for patients with In-Hospital Cardiac Arrest (IHCA) remains unclear. There have been no RCTs and results of observational studies have been conflicting.
Methods: The PubMed, Cochrane and Web of Science databases were queried for clinical studies comparing the use of TH versus standard therapy for IHCA. The following search terms were used: hypothermia, targeted temperature management, in-hospital and cardiac arrest. The outcomes assessed were: the survival at hospital discharge and the neurological outcome using the Cerebral Performance Categories Scale (CPCS), a score of 2 or less was considered favorable. Analysis was conducted using RevMan 5.3 software with random effects model. Publication bias was assessed by visual inspection of the funnel plot. P value less than 0.05 was considered statistically significant.
Results: A total of 4 retrospective controlled studies with a total of 13667 patients (TH:1797; control: 11870) were included for analysis. There were no statistical differences between both arms in regards to survival at discharge (OR 0.92 [0.80-1.06], P < 0.26) or neurological outcomes (OR 1.89 [0.33-10.64], P < 0.47).
Conclusions: This meta-analysis suggests that TH for patients with IHCA does not improve survival or neurologic outcome. There is an urgent need for randomized controlled studies to address this question.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Arrhythmias and Clinical EP: Ventricular Tachycardia
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1108-078
- 2017 American College of Cardiology Foundation