Author + information
- Jess Lopattoa,b,
- Elizabeth Ebya,b,
- Daniel Lexcena,b,
- Lee J. Smolena,b,
- Charles Henriksona,b,
- Muhammad Sohaila,b and
- Grant Simonsa,b
Background: Recent clinical studies (Citadel/Centurion studies) demonstrated that the TYRX™ Antibacterial Envelope (TYRX) was associated with a significantly reduced rate of major Cardiovascular Implantable Electronic Device (CIED) Infections relative to published controls among patients at high risk for CIED Infection. The objective of this analysis is to quantify the hospital perspective economic impact associated with TYRX use, based upon the reduction in CIED infections demonstrated in the Citadel/Centurion studies.
Methods: A decision tree model was developed based on the population of 1,129 high risk CIED implant patients (40.7% ICD and 59.3% CRT) and TYRX use infection rates of 0.22% for ICD and 0.60% for CRT sourced from the Citadel/Centurion studies results. An infection rate of 2.22% for both ICD and CRT was sourced from the same published control utilized in the Citadel/Centurion studies. The model assumed that patients with major infections received inpatient treatment consisting of CIED extraction and replacement, per guideline recommendations. Inpatient hospital costs, specific for Medicare ICD and CRT patients but independent of TYRX use, were sourced from the Premier Healthcare Database as $75,697 and $87,533 for ICD and CRT-D, respectively. The TYRX cost was specified as $1,000.
Results: Per 1,129 patients, use of TYRX resulted in 20 fewer CIED infections (5 vs. 25). The total TYRX cost of $1,129,000 was offset by a $1,644,975 reduction in total CIED infection-related hospital costs, for a net cost savings of $515,975 or $457 per patient.
Conclusions: Use of TYRX in a high risk CIED population resulted in fewer CIED infections, with a resultant reduction in hospital costs. The reduction in CIED infection-related hospital costs was greater than the TYRX costs, resulting in overall cost savings.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Devices 2
Abstract Category: 5. Arrhythmias and Clinical EP: Devices
Presentation Number: 1149-073
- 2017 American College of Cardiology Foundation