Author + information
- Abhilash Akinapelli,
- Aashay Patel,
- Abdulghani Saadi,
- Muhammad Soubhi Azzouz,
- Arun Kanmanthareddy,
- Alok Saurav and
- Ahmed Aboeata
Background: Implantable cardioverter defibrillator (ICDs) have been shown to reduce all-cause mortality in patients with ischemic and non-ischemic cardiomyopathy (NICM). However, the necessity of ICDs in NICM patients has been questioned in recent randomized controlled studies. Due to this equipoise, we performed systematic review and meta-analysis of studies evaluating the efficacy of ICDs in NICM.
Methods: Pubmed, Cochrane, and EMBASE databases were queried to identify the studies evaluated the efficacy of ICDs in primary prevention of mortality primarily in patients with NICM. The analysis was performed following the PRISMA guidelines using random effects model.
Results: There were 4 randomized controlled trials included primarily NICM patients. A total of 1677 patients were included in the analysis. There was no significant difference in the all-cause mortality (Risk ratio 0.88 [0.73-1.07]; p-value 0.21) and cardiovascular death (Risk ratio 0.66 [0.42-1.03]; p-value 0.07). However sudden cardiac death was lower in ICD group (Risk ratio 0.47 [0.30-0.73]; p-value 0.0007).
Conclusions: In this analysis, ICDs were not associated with a decrease in all-cause mortality. More robust studies are needed targeting patients with high risk for sudden cardiac death.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Devices 2
Abstract Category: 5. Arrhythmias and Clinical EP: Devices
Presentation Number: 1149-076
- 2017 American College of Cardiology Foundation