Author + information
- Valay Parikh,
- Krzysztof Bartus,
- Madhu Reddy,
- Randall Lee and
- Dhanunjaya Lakkireddy
Background: Left atrial appendage closure (LAAC) with LARIAT has emerged as one of the alternatives to oral anticoagulation (OAC) in patients with non-valvular atrial fibrillation (AF). Our aim was to study long-term outcomes in patients undergoing LARIAT procedure.
Methods: We analyzed 88 patients with CHA2DS2VASc score ≥2 screened for LARIAT procedure with 5 years of follow-up. 57 pts underwent LARIAT procedure and the rest (n= 31) who were screened out for the procedure were included in control group. OACs were continued in 61% patients. We analyzed thromboembolic risk and mortality between LAAC and control group. We also analyzed bleeding risk in LAAC subgroups with OACs and no-OACs.
Results: All the patients were followed up for > 4.5 years. There were no differences in baseline characteristics except HAS-BLED score. Mean HAS-BLED score was significantly higher in LARIAT group (3.6 ± 1 vs 3 ± 1.3, p=0.009). No patient in LAAC group had thromboembolic events, while 3 patients in control group had thromboembolic events. Bleeding episodes were significantly higher in OAC subgroup of LARIAT group (31% vs 6%; p=0.04), primarily driven by minor bleeding episodes.
Conclusions: LAA closure with LARIAT is associated with lower thromboembolic risk in patients with non-valvular AF. It is also associated with lower bleeding risk in patients with high HAS-BLED score if OACs were not used.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Devices 2
Abstract Category: 5. Arrhythmias and Clinical EP: Devices
Presentation Number: 1149-079
- 2017 American College of Cardiology Foundation