Author + information
Aim Non-platelet thromboxane generation, measured by urinary 11-dehydroTXB2 in subjects on aspirin therapy, has been shown to be independently associated with vein graft thrombosis 6 months after coronary artery bypass graft (CABG) surgery. We investigated its ability to predict, along with other patient demographic, clinical and laboratory factors, late-term outcome after CABG surgery.
Methods: We analyzed data from 293 subjects enrolled in the multicenter Reduction in Graft Occlusion Rates study who were on aspirin therapy and survived to graft patency assessment 6 months after CABG surgery. The primary endpoint was the composite of mortality, myocardial infarction (MI), stroke and repeat revascularization with mortality as a secondary endpoint. Post-operative events prior to the 6 month evaluation (194±30 days) were excluded. Proportional hazard Cox survival modeling was used to assess determinants of outcome. Predictors reaching significance (unadjusted p<0.05) on univariate modeling were considered in an initial multivariate Cox survival model that was optimized by backward stepwise modeling with bootstrapping.
Results: There were 67 primary endpoints, including 26 mortalities, during a mean follow-up period of 1566±484 days. Independent predictors of outcome on multivariate modeling are shown below.
Conclusions: Non-platelet thromboxane generation 6-months after CABG surgery is a significant independent predictor of late-term events, including mortality.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Novel Mechanisms Underlying Ischemia-Reperfusion Injury in AMI
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1124-300
- 2017 American College of Cardiology Foundation