Author + information
- Pattara Rattanawong,
- Tanawan Riangwiwat,
- Veeravich Jaruvongvanich,
- Sikarin Upala,
- Anawin Sanguankeo,
- Wasawat Vutthikraivit and
- Eugene Chung
Background: Sudden cardiac death (SCD) was reported as the most common cause of cardiovascular death in patients with atrial fibrillation (AF). Recent studies also suggest that AF is associated with increased cardiovascular risk and mortality including SCD. In this study, we performed a systematic review and meta-analysis to explore the association between atrial fibrillation and SCD.
Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to August 2016. Included studies were published prospective or retrospective cohort studies that compared the risk of developing SCD in AF patients versus non-AF patients. Data from each study were combined using the random-effects model, generic inverse variance method of DerSimonian and Laird to calculate the risk ratios and 95% confidence intervals.
Results: Eighteen studies from 1991 to 2016 involving 9,492 AF patients and 88,983 non-AF controls were included in the meta-analysis. Compared with controls, AF patients had a significantly higher risk of SCD (pooled risk ratio=1.841, 95 % confidence interval: 1.447-2.341, p < 0.001, I2=83.854).
Conclusions: Our meta-analysis demonstrates a statistically significant increased risk of SCD among patients with AF. SCD should be considered in patients with atrial fibrillation. Independent predictors of SCD in AF patients should be further identified.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Atrial Fibrillation and VT: Unique Populations and Solutions
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1151-096
- 2017 American College of Cardiology Foundation