Author + information
- Alex H. Velasquez,
- Fiorella Llanos-Chea,
- Ignacio De Ciccio,
- S. Humayun Naqvi,
- Victor Liu and
- Anne Dougherty
Background: Colchicine has been established to decrease the incidence of post-operative atrial fibrillation(POAF). This study aimed to determine relationship between the timing of colchicine administration and the incidence of POAF in cardiac surgical patients.
Methods: This is a retrospective cohort study including patients who underwent aorto-coronary bypass or valvular cardiac surgery between 2011 and 2015 at our center. Early administration of colchicine was defined as administration before the first 2 post-operative days while late administration included administration beyond 2 post-operative days. For comparison a control group of 632 patients was used to determine baseline atrial fibrillation risk.
Results: 82 and 130 patients received perioperative colchicine early and late respectively for a total of 217 cardiac surgical patients. 2(2.4%), 10(7.7%) and 213(34%) of patients developed POAF.
Conclusions: Patients who received colchicine were less likely to develop POAF after cardiac surgery when compared to a control population. However, although patients who received early colchicine had a lower incidence of POAF when compared to those who received it late, this difference did not meet statistical significance. This trend to benefit may also reflect selection bias in the treatment group toward a healthier population.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Atrial Fibrillation and VT: Unique Populations and Solutions
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1151-101
- 2017 American College of Cardiology Foundation