Author + information
- Steffen Christow,
- Karlheinz Seidl,
- Hans-Christoph Diener,
- Menno Huisman,
- Gregory Lip,
- Ursula Rauch-Kroenert,
- Stefan Schuster,
- Johannes Brachmann,
- Andreas Muegge,
- Peter Schwimmbeck,
- Christine Teutsch and
- Jochen Senges
Background: GLORIA-AF is a global, observational, registry program involving up to 56,000 patients (pts.) with newly diagnosed, non-valvular atrial fibrillation (NVAF) at risk for stroke in 44 countries worldwide.
The aim of this sub-analysis was to compare patient characteristics between symptomatic (symp.) and asymptomatic/minimally symptomatic (asymp./minisymp.) NVAF pts. worldwide.
Methods: Eligibility requirements included newly diagnosed NVAF (<3 months before baseline visit) in consecutive pts. at risk for ischemic stroke (CHA2DS2-VASc score ≥1). Univariate logistic regressions were used. Odds ratios and P-values are reported.
Results: The characteristics of 15,080 enrolled pts. are shown in the table. Main findings are:
1. 10,819 (72%) pts. with newly diagnosed AF were asymp./minisymp.
2. For pts. with asymp./minisymp. AF, ejection fraction and congestive heart failure were less frequently observed while permanent AF was more frequent.
3. The CHA2DS2-VASc scores did not differ in symp. and asymp./minisymp. pts.
4. 11.8% of asymp./minisymp. pts. had a history of stroke prior to enrollment compared with 7.2% of symp. pts. (p< 0.0001).
Conclusions: Worldwide more than two thirds of pts. with newly diagnosed NVAF are asymp./minisymp. The high rate of previous stroke in these pts. despite no differences in CHA2DS2-VASc score may be explained by a longer, but occult AF history. The results underline demands for public programs to detect NVAF in the general population.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Atrial Fibrillation and VT: Specific Situations and Newer Outcome Measures
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1190-098
- 2017 American College of Cardiology Foundation