Author + information
- Patrick Zakka,
- Mohammad Karnib,
- Maria Matar,
- Sami Bdeir,
- Moustafa Al Hariri,
- Mirna Ghemrawi,
- Jad Ballout,
- Rami Mahfouz,
- Ayad Jaffa,
- Bernard Abi Saleh,
- Maurice Khoury,
- Samir Alam and
- Marwan Refaat
Background: Atrial fibrillation (AF) and cardiometabolic syndrome (CMS) have been linked to inflammation and fibrosis. We investigated inflammatory and fibrotic markers as well as cytokine genetic profiles in patients with lone AF and CMS.
Methods: This study has three groups: CMS patients, lone AF patients, and patients with both lone AF and CMS. We assessed for genetic polymorphisms in inflammatory and fibrotic markers. Serum levels of connective tissue growth factor were tested along with other inflammatory markers including platelet-to-lymphocyte ratio (PLR), monocyte-to-HDL ratio (MHR), and red cell distribution width (RDW).
Results: 39 patients (15 AF + CMS, 11 AF, 13 CMS) were tested. Connective tissue growth factor levels were highest in the AF + CMS group and lowest in the AF group (no statistical significance). PLR was highest in groups with CMS and lowest in the AF group (p < 0.05). Genotyping showed high percentages of patients in all groups with high secretor genotypes of transforming growth factor beta 1 and interleukin-6. No significant difference was seen in the RDW nor the MHR between groups.
Conclusions: Connective tissue growth factor levels and PLR showed a pattern of being highest in the group with both AF + CMS, and lowest in the AF group. Genotyping showed high percentages of patients with high secretor genotypes of interleukin-6 and transforming growth factor beta 1. Combination of both CMS and AF may be associated with a higher degree of inflammation than what is seen in either CMS or AF alone.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias and Clinical EP: Basic 3
Abstract Category: 4. Arrhythmias and Clinical EP: Basic
Presentation Number: 1191-116
- 2017 American College of Cardiology Foundation