Author + information
- Christian T. Ruff,
- Dov Shiffman,
- James Devlin,
- Robert Giugliano,
- Elliott Antman,
- Marco Trevisan,
- Francesco Nordio,
- Alexander Vandell,
- Michele Mercuri and
- Marc Sabatine
Background: Single nucleotide polymorphisms (SNPs) have been associated with the risk of incident atrial fibrillation (AF). We tested whether an established AF genetic risk score (AF-GRS) was associated with the burden of AF in patients with established AF in the ENGAGE AF-TIMI 48 trial.
Methods: Investigators classified AF burden as paroxysmal, persistent, or permanent AF at randomization. Genotypes for 12 validated AF SNPs were determined in 13,415 patients who provided a DNA sample using a multiplex method (Quest Diagnostics). The AF-GRS for each patient was calculated by multiplying the number of minor alleles for each SNP by the log-transformed risk estimate for the minor allele of that SNP and adding up these 12 products for each patient. The association between AF-GRS and AF burden was examined using a proportional odds model with multivariable adjustment for differences in baseline characteristics across AF-GRS.
Results: There was strong graded relationship between AF-GRS and AF burden. For each 1-SD higher AF-GRS, patients had a 13% higher multivariable adjusted odds of having a greater burden of AF (p<0.0001). There was a gradient of risk across rising quintiles of AF-GRS (Figure) such that compared to those in the lowest quintile of AF-GRS, those in the highest quintile had a 42% greater adjusted odds of having a greater burden of AF (p-trend <0.0001).
Conclusions: An AF-GRS comprised of 12 SNPs associated with incident AF also was associated with the burden of AF in patients with known AF.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: AF Miscellaneous and Surgical Issues
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1236-080
- 2017 American College of Cardiology Foundation