Author + information
- Chang Kima,b,
- Leben Teferaa,b,
- Ben Alencherrya,b,
- Ahmad Tarek Chamia,b,
- Sadeer Al-Kindia,b and
- Christopher Longeneckera,b
Background: While human immunodeficiency virus (HIV) infection is a known risk factor for atherosclerotic cardiovascular disease, its association with atrial fibrillation (AF) is less well characterized. We sought to investigate the prevalence of AF and its association with HIV in a contemporary cohort.
Methods: Using a large, multi-institutional database (Explorys Inc, Cleveland, OH), we used multivariable logistic regression to explore associations between HIV status and prevalent AF among patients with encounters between October 2011 and September 2016.
Results: We identified 68,040 patients with HIV infection and 7,127,940 age- and gender-matched controls. AF was more prevalent in the HIV group (3.26% vs. 2.37%; OR 1.39 [95% CI 1.33-1.45]). The HIV-associated risk of AF tended to be higher in women compared to men (p for HIV*gender interaction <0.001; Figure). HIV was associated with AF (adjusted OR: 2.68 [2.50-2.86], p<0.001) independent of age, gender, race, hypertension, diabetes, smoking, heart failure, coronary artery disease, chronic kidney disease, alcohol abuse, and thyroid disease. Compared to those with nadir CD4+ T-cells >500/μL, those with nadir CD4 <200/μL had higher odds of AF (age-adjusted OR 1.83 [1.38-2.42], p<0.001]).
Conclusions: Risk of AF is increased in patients living with HIV in the era of antiretroviral therapy, especially among young females. This association between HIV and AF appears to be independent of a number of traditional risk factors for AF.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: AF Miscellaneous and Surgical Issues
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1236-082
- 2017 American College of Cardiology Foundation