Author + information
- Rachid A. Elkoustaf,
- Mohamed Ismail,
- Columbus Batiste,
- Adina Mercer,
- Omar Aldaas and
- Darlene Newton
Background: The cardio protective effects of various diet regimens in primary prevention have been studied and elucidated in registry data and more recently in a large randomized trial; however, there is a paucity of data regarding the effects of rigorous nutritional regimens in patients with established coronary heart disease (CHD) or CHD equivalent and more specifically vis a vis plaque regression
Methods: We performed a randomized single center, single-blind study design on 100 patients with established CHD. 50 patients were randomly assigned to an outpatient lifestyle program (18 education sessions lasting 2 hours each during the first 12 weeks and followed by monthly sessions thereafter) that emphasized a whole food, low fat, plant based diet. 50 other patients were randomly assigned to a similarly established outpatient healthy heart program with an emphasis on a Mediterranean regimen. didactic sessions and cooking demonstrations were provided by a certified health educator and a registered dietician. Baseline and 9 month change in carotid mean intima-media thickness were measured in the near and far wall of bilateral common carotid arteries. Additional testing (at baseline, 6 weeks, 3 months, 6 months and 9 months) included pre specified secondary endpoints, including but not limited to fasting serology (cholesterol, lipoprotein (a), C-reative protein, hemoglobin A1C) blood pressure, body mass index, angina score, 6 minute walk test.
Results: Overall, there was no significant difference in CIMT regression over the 9 month study period between the two groups. There were early and marked differences in the secondary end point of BMI favoring the plant based group vs the Mediterranean group. Additionally, there were statistically significant within group differences in systolic/diastolic blood pressure, triglycerides, angina score, 6 minute walk test, self assessment well being score, and dietary block questionnaire.
Conclusions: Neither a plant based diet nor a Mediterranean diet were effective in inducing plaque regression in patients with established coronary artery disease after a 9 month period.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Updates in Stable Ischemic Heart Disease
Abstract Category: 3. Acute and Stable Ischemic Heart Disease: Therapy
Presentation Number: 1125-308
- 2017 American College of Cardiology Foundation