Author + information
- Shah Banoa,b,
- Usman Salahuddina,b,
- Sushil Garga,b,
- Nitin Kulkarnia,b,
- Vidhu Ananda,b,
- Helen Mayoa,b,
- Shreya Raoa,b and
- Ambarish Pandeya,b
Background: Higher BMI and obesity is associated with increased risk of atrial fibrillation (AF). However, the impact of BMI and obesity on prognostic outcomes among patients with prevalent AF is not well-established.
Methods: We performed a systematic search of electronic databases for prospective cohort studies that evaluated the associations between BMI and risk of adverse clinical outcomes among individuals with prevalent AF. Outcomes of interest included stroke and all-cause mortality. The BMI categories across different studies were harmonized and the dose-response association was evaluated by pooling the hazard ratio (HR) for stroke and all-cause mortality associated with different levels of BMI (vs. normal BMI) using random-effect modeling technique.
Results: Six prospective cohort studies with 34,429 participants with 1,215 stroke events and 3,322 all-cause mortality events reported over a median follow-up of 3 years were included in the meta-analysis. In pooled analysis, compared with normal weight (median BMI = 21.7kg/m2) group, obese participants (median BMI= 32.5 kg/m2) had a significantly lower risk for all-cause mortality [HR 95% CI: 0.77(0.55 – 0.99)]. However, the protective effect of BMI against mortality was not statistically significant among overweight participants [(median BMI = 27.5 kg/m2); HR (95% CI): 0.80 (0.60 – 1.01)]. For stroke outcome, we did not observe any significant association between BMI categories and risk of stroke [Overweight vs. normal weight HR (95% CI): 0.92 (0.78 – 1.06)]; obese vs. normal weight: [HR (95% CI): 0.87 (0.71 – 1.02)].
Conclusions: In this pooled analysis, we observed a lower risk for all-cause mortality but not stroke among obese vs. normal weight patients with prevalent AF.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: AF Miscellaneous and Surgical Issues
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1236-088
- 2017 American College of Cardiology Foundation