Author + information
- Muhammad Asif Mangi,
- Abdul Manan,
- Hiba Rehman,
- Furquan Pathan,
- Hong Liang and
- Sary Beidas
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed countries. Recently, NAFLD association with cardiovascular atherosclerosis was identified. The aim of our study was to find whether an association exists between heart block and NAFLD.
Methods: This is a case-control retrospective study of 700 patients (140 patients with heart block, and 560 without heart block) admitted to Orange Park Medical Center, Jacksonville from 2009 to 2015. Patients with a history of alcohol use, congenital heart disease, infiltrative malignancy, and myocarditis were excluded from the study. NAFLD was diagnosed by detection of hepatic steatosis on ultrasound or CT scan. Electrocardiograms were performed on all 700 patients and were interpreted by a cardiologist. Univariate logistic regression was used to assess potential risk factors of heart block, and multivariate logistic regression with backward elimination method was performed to determine if NAFLD was an independent risk factor for Heart Block.
Results: Mean age was 58 years, 42% were males and 58% females, 76.4% Caucasian, 14% African Americans, 0.02% Hispanics and 0.07% were other race. There were 155 total AV block events observed in 140 patients. Of these patients, 36 (25.7%) had 1st degree block, 3 (2.1%) had Mobitz type 1 block, 58 (41.4%) had Right bundle branch block, 25 (17.9%) had left bundle branch block, 16 (11.4%) had bi-fascicular block, and 17 (12.1%) had nonspecific intraventricular block. Multivariate logistic regression with backward elimination method identified 7 independent risk factors for heart block. These factors included NAFLD (OR 1.92; 95% CI 1.20-3.08, p=0.0063), Hypertrophy (OR 2.30; 95% CI 1.43-3.72, p=0.0007), Axis deviation (OR 3.09; 95% CI 1.92-4.96, p<0.0001), Atrial fibrillation (OR 2.33; 95% CI 1.33-4.07, p=0.0032), PAC/PVC (OR 1.71; 95% CI 1.04-2.81, p=0.0337), diabetes (OR 1.70; 95% CI 1.11-2.60, p=0.0145), and age (OR 1.03; 95% CI 1.01-1.04, p=0.0018).
Conclusions: This study suggests that NAFLD is an independent risk factor for Heart block. We recommend a prospective randomized trial to identify if heart block is directly caused by NAFLD.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Basic 4
Abstract Category: 4. Arrhythmias and Clinical EP: Basic
Presentation Number: 1238-113
- 2017 American College of Cardiology Foundation