Author + information
- Pattara Rattanawong,
- Wasawat Vutthikraivit,
- Weera Sukhumthammarat,
- Prapaipan Putthapiban and
- Tachapong Ngarmukos
Background: Brugada syndrome (BrS) is reported to be an important etiology of sudden cardiac death in Asian population. Prevalence of BrS has been reported in various regions, countries, and ethnicities. Our study is the first systematic review and meta-analysis assessing worldwide prevalence of BrS among difference regions, countries, and ethnicities.
Methods: We comprehensively searched the databases of MEDLINE, EMBASE, and conference proceeding from inception to August 2016. Included studies were published prevalence studies of type-1 and type-2 Brugada pattern (BrP). BrS was defined as presence of type-1 BrP according to the recent diagnostic criteria of European Society of Cardiology. Estimated prevalence was obtained using random effects models. Meta-regression analysis was used to explore the sources of heterogeneity. Publication bias was evaluated by funnel plots.
Results: Overall, 28 articles (n=380,087) were included in this study. Worldwide prevalence of BrS was estimated at 0.01%. Over 82.0% of BrS were male. BrS was twice as common in Asian as in Caucasian (0.02% vs 0.01%, respectively). The prevalence of BrS was found to be highest in Southeast Asia (0.25%, 95% CI: 0.22-0.29%) followed by Middle East (0.23%, 95% CI: 0.20-0.27%), South Asia (0.18%, 95%CI: 0.10%-0.26%), Europe (0.04%, 95% CI: 0.03-0.04%), East Asia (0.02%, 95% CI: 0.01-0.02%), and North America (0.01%, 95% CI: 0.00-0.01%%). As well as type-2 BrP, the prevalence was found to be highest in Southeast Asia (1.37%, 95% CI: 1.29-1.46%) followed by Middle East (1.08%, 95% CI: 1.00-1.15%), South Asia (0.64%, 95%CI: 0.49-0.78%), East Asia (0.27%, 95% CI: 0.26-0.28%), Europe (0.12%, 95% CI: 0.11-0.13%), and North America (0.01%, 95% CI: 0.01-0.01%). When the prevalence studies were pooled by country, Thailand had the highest prevalence of BrS in the world (0.48%, 95% CI: 0.41-0.55%).
Conclusions: Worldwide prevalence of BrS was estimated at 0.01%. BrS was male preponderance and highly prevalent in Southeast Asia. Thailand had highest prevalence of BrS in the world. ECG screening should be considered for early detection in an endemic area.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias and Clinical EP: Syncope and Other EP Issues
Abstract Category: 6. Arrhythmias and Clinical EP: Other
Presentation Number: 1279-084
- 2017 American College of Cardiology Foundation