Author + information
- Jes Sanders,
- Alexandra Steverson,
- Anna Pawlowski,
- Daniel Schneider,
- Prasanth Nannapaneni,
- Sanjiv Shah,
- Chad J. Achenbach,
- Donald Lloyd-Jones and
- Matthew Feinstein
Background: HIV+ persons have elevated risks for various manifestations of cardiovascular disease (CVD), but no studies to our knowledge have evaluated AF and AFL for HIV+ persons and matched uninfected controls.
Methods: Patients from an electronic cohort of 5,052 HIV+ patients and 10,121 uninfected controls (propensity-matched on demographics and zip code) were screened for possible AF/AFL using ICD-9 and CPT codes; physician chart review subsequently adjudicated AF/AFL based on electrocardiographic evidence and/or physician notes. Prevalence of AF/AFL was compared for HIV+ versus uninfected persons, and across levels of immunosuppression among HIV+ persons, using multivariable logistic regression.
Results: There were 101 confirmed AF/AFL cases (2.00%) among HIV+ patients and 159 confirmed AF/AFL cases (1.57%) among uninfected controls [Odds Ratio (OR) 1.27, 95% Confidence Interval (CI) 0.99-1.64; p=0.056] (Figure 1). This elevated AF/AFL burden was attenuated to non-significance (p=0.40) after adjustment for diabetes and hypertension. Compared with HIV+ persons with nadir CD4+ T cell count ≥500 cells/mm3, those with nadir CD4+ T cell count <200 cells/mm3 were significantly more likely to have AF/AFL after adjustment for demographics and CVD risk factors (OR 3.18, 95% CI 1.22-8.23; p=0.02).
Conclusions: Atrial fibrillation and atrial flutter appear to be more common among HIV+ persons than uninfected controls and associated with cardiovascular risk factors and HIV-related factors.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Atrial Fibrillation and VT: Incorporating Novel Risks Toward Decision Making
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1280-101
- 2017 American College of Cardiology Foundation