Author + information
- Arun Kanmanthareddy,
- Madhu Reddy,
- Dixitha Anugula,
- Venkata Alla,
- Claire Hunter,
- Aryan Mooss,
- Madhav Lavu,
- Sudharani Bommana,
- Donita Atkins,
- Andrea Natale and
- Dhanunjaya Lakkireddy
Background: Supraventricular arrhythmias such as atrial fibrillation(AF) and atrial flutter are common after cardiac surgery. Wecompared the efficacy of Sotalol compared to other agents for the prevention of these arrhythmias after cardiac surgery.
Methods: We searched PubMed, Google Scholar and EBSCO databases to identify studies comparing sotalol with other antiarrhythmicmedications for the prevention of supraventricular arrhythmias after cardiac surgery. We then synthesized the data using STATA 13 software to estimate the risk ratio (RR) and 95% CI for occurrence of these arrhythmias.
Results: A total of 6 randomized controlled studies with 1,328 patients were included. Sotalol versus beta-blockers were compared in 5 studies and sotalol with amiodarone was compared in 2 studies. Supraventricular arrhythmias occurred in 14% and 23% of the sotalol andbeta-blocker groups, respectively. Sotalol group had a lower incidence of these arrhythmias compared to beta-blockers (RR 0.69,95% CI 0.53 – 0.91). The incidence of these arrhythmias was 28% and 23% in the sotalol and amiodarone groups, respectively. There was no difference between sotalol and amiodarone groups (RR 1.18, 95% CI 0.78 – 1.78).
Conclusions: Sotalol appears to be superior to beta-blockers but similar in efficacy to amiodarone in preventing supra ventricular tachyarrhythmias after cardiac surgery.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Atrial Fibrillation and VT: Incorporating Novel Risks Toward Decision Making
Abstract Category: 8. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1280-108
- 2017 American College of Cardiology Foundation