Author + information
- Laith Alshawabkeh,
- Saurabh Rajpal,
- Michael Landzberg,
- Catherine Gray,
- Fred Wu,
- Georges Ephrem and
- Alexander Opotowsky
Background: Red cell distribution width (RDW) is a strong predictor of adverse outcomes in diverse populations. We investigated the prognostic value of RDW as a marker of risk in adults with congenital heart disease (CHD).
Methods: To test our hypothesis that RDW is a predictor of death or non-elective cardiovascular hospitalization, we prospectively enrolled 702 adults with CHD between 2012 and 2016 to investigate the association between RDW and outcomes. Survival analysis was used to model the relationship between RDW and the outcomes of interest.
Results: Mean age was 38.7±13.5 years and 49.9% were female. Most patients had either moderately (42.5%) or severely complex (38.8%) CHD. Median RDW was 13.7% [interquartile range 13.3 – 14.3%, RDW>15% in 84/702]. Median follow up for the combined outcome in 530 patients with longitudinal data was 364 days; there were 18 deaths and 60 non-elective cardiovascular hospitalizations; higher RDW was associated with an increased hazard for the combined outcome (HR per +1SD RDW=1.6, 95%CI 1.4 – 1.8, p<0.0001) and for mortality alone (HR=2.0, 95%CI 1.6 – 2.5, p<0.0001) (Figure). RDW was an independent predictor of the combined outcome after adjusting for age, sex, CHD complexity, hemoglobin, cyanosis, and estimated glomerular filtration rate (HR=1.4, 95%CI 1.2-1.7, p<0.0001).
Conclusions: Elevated RDW is an independent predictor of death or non-elective cardiovascular hospitalizations in adults with CHD.
Moderated Poster Contributions
Congenital Heart Disease and Pulmonary Hypertension Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-9:55 a.m.
Session Title: Things That Matter in Adult Congenital Heart Disease
Abstract Category: 9. Congenital Heart Disease: Adult
Presentation Number: 1302M-03
- 2017 American College of Cardiology Foundation