Author + information
- Geoffrey Huntley,
- Heidi Connolly,
- Sameh M. Said,
- Carole Warnes,
- Christopher McLeod and
- Alexander C. Egbe
Background: Cardiac pacing can be challenging after a Fontan operation, and there are limited data about pacing in adults with Fontan palliation.
Methods: A retrospective review of adult Fontan patients followed at Mayo Clinic between 1994 and 2014 was conducted in order to determine the risk factors for pacing and occurrence of device-related complications (DRC) and pacemaker reinterventions. DRC was defined as lead failure, lead recall, lead thrombus/vegetation, or device related infection. Cardiovascular adverse event (CAE) was defined as venous thrombosis, stroke, death, or heart transplant.
Results: Out of 439 adult Fontan patients, 166 (38%) required pacing (79 and 87 had pacemaker implantation in childhood and adulthood, respectively). At initial implantation, 114 patients (69%) received epicardial leads, and 52 patients (31%) received endocardial leads. Initial pacing mode was atrial (n=52, 31%), ventricular (n=30, 18%), and dual chamber (n=84, 51%). Risk factors for pacing included atrial arrhythmia (hazard ratio [HR] 2.21, 95% confidence interval [CI] 1.33-5.11, P=0.04) and reoperation (HR 1.98, CI 1.16-6.12, P=0.02). There were 129 reinterventions (lead failure 39, lead recall 6, generator change 62, defibrillator upgrade 4, cardiac surgery 18). Excluding generator changes, the reintervention rate was 3.3% per year. There were 48 DRCs (lead failure 31, lead recall 6, lead thrombus/vegetation 5, and infection 6), yielding a DRC rate of 2.4% per year. Pacemaker implantation in childhood was a risk factor for DRC (HR 2.01, CI 1.22-5.63, P=0.03). There were 70 CAE (venous thrombosis 5, stroke 11, transplant 8, and death 46), yielding a rate of 3.5% per year. DRC, CAE, and reintervention rates were comparable between epicardial and endocardial leads.
Conclusions: More than one-third of adult Fontan patients referred to the Mayo Clinic required pacing. Atrial arrhythmias and reoperations were risk factors for pacemaker implantation. Outcomes of epicardial and endocardial leads were comparable.
Moderated Poster Contributions
Congenital Heart Disease and Pulmonary Hypertension Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 10:15 a.m.-10:25 a.m.
Session Title: Things That Matter in Adult Congenital Heart Disease
Abstract Category: 9. Congenital Heart Disease: Adult
Presentation Number: 1302M-07
- 2017 American College of Cardiology Foundation