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Background: Cannabis is the most commonly abused illicit drug in the world, yet its effect on the cardiovascular system remains largely unknown. We sought to investigate the incidence of myocardial infarction (MI) and its association with cannabis abuse in a contemporary cohort.
Methods: Using a large, multi-institutional database (Explorys Inc, Cleveland, OH), we performed a retrospective, matched cohort analysis on patients with encounters between October 2011 and September 2016. Multiple logistic regression analysis was performed to explore the association between cannabis abuse, MI, and cardiovascular risk factors.
Results: We identified 210,700 patients with cannabis abuse and 10,395,060 age-matched controls. Five-year cumulative incidence of MI was significantly higher in the cannabis group compared to controls (1.28% vs. 0.89%, relative risk (RR) 1.44 [95% CI: 1.39-1.50]). There was greater risk in the young, with RR 3.20 [2.51-4.07] for ages 25-29 and RR 4.56 [3.75-5.54] for ages 30-34 (Figure). In multivariable analysis, cannabis abuse was significantly associated with MI (odds ratio 1.72 [1.67-1.77]), p<0.0001), independent of advanced age, hypertension, coronary artery disease, diabetes, smoking, alcohol abuse, and cocaine abuse.
Conclusions: Incidence of MI is increased and independently associated with cannabis abuse, with higher RR in younger ages. Further studies are needed to confirm these findings.
Room 150 A
Sunday, March 19, 2017, 9:17 a.m.-9:27 a.m.
Session Title: Highlighted Original Research: Acute and Stable Ischemic Heart Disease and the Year in Review
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 907-14
- 2017 American College of Cardiology Foundation