Author + information
- Luis Almeida-Morais,
- Lidia Sousa,
- Antonio Fiarresga,
- Ana T. Timoteo,
- Jose Diogo Martins,
- Filipa Ferreira,
- Jose Alberto Oliveira,
- Cristina Soares,
- Ana Agapito,
- Fatima Pinto and
- Rui Ferreira
Background: Patent foramen ovale (PFO) closure global benefits for cryptogenic stroke secondary prevention remain controversial. The Risk of Paradoxical Embolism (RoPE) study developed a score to improve patient selection. It's our purpose to assess the validity of this score to predict long-term outcomes.
Methods: From 2000-2014, all consecutive patients submitted to percutaneous PFO closure were included in a prospective registry in a university centre. The primary endpoint was ischemic cerebral events (ICE) recurrence and secondary endpoints were all cause mortality and new onset atrial fibrillation (AF).
Results: 403 patients were submitted to PFO closure (females 52.1%, mean age 44.7±10.9 yo). Mean follow-up: 6.4±3.7 years. Immediate success: 97%. 8 deaths, 23 ICE and 17 new onset AF cases were reported. Smoking (OR 3.3, 95% CI 1.2-8.5, p=0.014), coronary disease (CD) (OR 6.7, 95% CI 1.9-23.1, p=0.003), low RoPE score (≤6) (OR 6.5, 95% CI 1.5-28.2, p=0.012) and left atrial dimension (OR 1.1, 95%CI 1.0-1.2, p=0.037) were predictors of primary endpoint. After multivariate analysis, low RoPE score (OR 5.6, 95% CI 1.3-24.5, p=0.024) and CD (OR 7.7, 95% CI 1.9-30.3, p=0.033) remained independent predictors. All cause mortality and new onset AF were significantly higher in the low RoPE score group (p<0.05).
Conclusions: RoPE score was shown to be an independent long-term predictor of ICE recurrence and a score ≤6 identifies patients with significantly higher mortality and ischemic events recurrence risk.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Pediatric Catheterization and EP: Mending, Fixing and Predicting
Abstract Category: 11. Congenital Heart Disease: Therapy
Presentation Number: 1144-022
- 2017 American College of Cardiology Foundation