Author + information
- Ilana Schwartz,
- Courtney McCracken,
- Christopher Petit and
- Ritu Sachdeva
Background: Though there are numerous single center reports of Fontan outcomes, there is lack of comprehensive survival data. The purpose of this meta-analysis was to evaluate the long-term outcomes following Fontan operation and to assess risk factors for mortality.
Methods: PubMed, Embase and Web of Science were queried to retrieve studies published since 2000 in English language with > 20 patients, that reported survival after Fontan procedure with ≥ 5 years of followup. A random effects model was used to calculate pooled survival estimates at 5, 10 and 15 yrs, and rates of death, transplant and complications. Meta-regression was used to assess the association between study characteristics and survival.
Results: Of the 630 articles retrieved, 19 with a total of 5,859 patients (mean follow-up 8.88 ± 3.35 yrs) met the inclusion criteria. Pooled survival estimates at 5, 10 and 15 yrs were 91.1%, 87.6% and 87.5% respectively. Event rates for death, transplant, complications and meta-regression for total deaths is shown in the Table. Arrhythmias and pacemaker implantation were the most common long-term complications. Significantly increased rates of death were associated with earliest surgical year, atriopulmonary connection, and older age at Fontan, but not with systemic right ventricle.
Conclusions: Though long-term survival after Fontan has improved with time, many have complications. The survival is influenced by Fontan type and age of patients, but not by the systemic ventricular morphology.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Congenital Heart Disease: Innovations in Single Ventricle Heart Disease
Abstract Category: 10. Congenital Heart Disease: Pediatric
Presentation Number: 1182-012
- 2017 American College of Cardiology Foundation