Author + information
- Shahryar Chowdhury,
- Eric Graham,
- Carolyn Taylor,
- Geoffrey Forbus,
- Andrew Savage and
- Andrew Atz
Introduction: Patients with single ventricle physiology frequently demonstrate decreased exercise tolerance after the Fontan operation. The objective of this study was to investigate the contribution of diastolic function to exercise function in these patients.
Methods: Core-lab echocardiograms and exercise test results were obtained from the publically-available Pediatric Heart Network Fontan Cross-sectional Study database. Exercise function was quantified as % predicted peak VO2. Ejection fraction (EF) was considered abnormal if < 50%. End-diastolic volume (EDV) was indexed to body surface area1.4. Diastolic function was defined as abnormal lateral E:e’/EDV was > 10th percentile. Patients were divided into three groups: 1 = normal EF and normal diastolic function, 2 = normal EF with abnormal diastolic function, and 3 = decreased EF with normal diastolic function. There were an inadequate number of patients with both abnormal EF and diastolic dysfunction to be included in the analysis.
Results: 185 patients (61% left, 29% right, 10% mixed ventricular dominance) had EF, lateral E:e’/EDV, and peak VO2 measured. Differences between groups are reported in the Table.
Conclusions: Single ventricle patients with abnormal diastolic function and preserved EF had worse exercise capacity than patients with both normal and abnormal EF. Diastolic dysfunction appears to be an important limitation to exercise function in this population. Echocardiography may be useful in detecting this subset of patients.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Congenital Heart Disease: Innovations in Single Ventricle Heart Disease
Abstract Category: 10. Congenital Heart Disease: Pediatric
Presentation Number: 1182-013
- 2017 American College of Cardiology Foundation