Author + information
- Neha J. Pagidipati,
- Puza Sharma,
- Anne Hellkamp,
- Tracy Wang,
- Gregg Fonarow and
- Michael Pencina
Background: The extent to which levels of high-sensitivity C-reactive protein (hs-CRP), a known marker of increased cardiovascular (CV) risk in patients with history of myocardial infarction (MI), are elevated and are associated with standard CV risk factors is unknown.
Methods: Regression splines accounting for sampling weights were used to describe the association of hs-CRP levels and 14 standard CV risk factors among participants from the 1999-2010 National Health and Nutrition Examination Survey (NHANES) who had history of MI and available hs-CRP.
Results: Among 1,296 individuals with a history of MI, median age was 65 years (IQR 55, 75) and median hs-CRP level was 2.69 mg/l, measured on average 7.1 years after the MI with 61% of the population ≥ 2mg/l. The Figure presents associations of hs-CRP with continuous CV risk factors. Mean hs-CRP was also higher in women (3.5 vs 2.6; p=0.015) and among non-smokers (4.1 vs 2.3; p<.001). Standard CV risk factors accounted for only 16% of the variability in hs-CRP.
Conclusions: Among those with a history of MI, hs-CRP was available in 1,296 subjects who were used for this analysis. Elevated hs-CRP is prevalent in this population and standard CV risk factors explain only a small proportion of the hs-CRP variability. This opens the possibility of an independent effect of hs-CRP on adverse CV outcomes in this population, which warrants investigation in prospective studies.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Traditional and Novel Factors Used to Assess the Risk of, and Used for the Treatment of, Coronary Artery Disease
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1126-324
- 2017 American College of Cardiology Foundation