Author + information
- Dora Gyenes,
- Jesus Serrano-Lomelin,
- Venu Jain,
- Claudine Bohun,
- Winnie Savard,
- Angela McBrien and
- Lisa Hornberger
Background: Maternal diabetes mellitus (DM), which affects 6-7% of pregnancies, is associated with fetal myocardial hypertrophy and altered diastolic function later in gestation, but its impact on the fetal heart earlier in gestation has received minimal attention. We sought to determine if maternal DM impacts fetal heart function at 8-15 weeks of gestation and to elucidate the role of maternal glycemic control.
Methods: Pregnancies complicated by DM and gestational age-matched healthy controls (1 DM: 2 controls) were prospectively recruited to undergo early fetal echocardiography. Pulsed Doppler-derived parameters of left (LV) and right ventricular function and the fetal circulation were compared between the groups. Maternal hemoglobin A1C values at <12 weeks gestation were collected.
Results: In total, 45 DM and 90 control pregnancies were studied (mean gestational age 12.4±1.5 weeks for both). The LV Tei index was significantly increased in fetuses of DM pregnancies (DM 0.52±0.14 vs control 0.43±0.11, p<0.001)(Figure). Other functional parameters did not differ between the groups, and A1C did not correlate with any functional parameter in our DM cohort.
Conclusions: Our pilot study suggests that maternal DM impacts global LV function of the 8-15 week fetus. Lack of correlation with maternal A1C suggests either a more complex relationship between maternal glucose control and fetal cardiac function or the presence of co-existing factors in the DM pregnancy.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Congenital Heart Disease: New Diagnostic Approaches in Congenital Heart Disease
Abstract Category: 10. Congenital Heart Disease: Pediatric
Presentation Number: 1231-013
- 2017 American College of Cardiology Foundation