Author + information
- Anita Saraf,
- Christine De Staercke,
- Fred Rodriguez,
- Andreas Kalogeropoulos,
- Andrea Knezevic,
- Jennifer Gerardin,
- Georges Ephrem,
- Salim Hayek,
- Staci Jennings,
- Agasha Katabarwa,
- Arshed Quyyumi and
- Wendy Book
Background: Fontan palliation causes systemic changes in hemodynamics resulting in multi-organ co-morbid conditions. We evaluated biomarker levels representative of various systemic pathways in stable Fontan patients in comparison with healthy controls.
Methods: We compared 23 stable Fontan patients, mean age 32.4 ± 9.02 yr, 46.9% female, 82.6% black, BMI of 26.6 ± 5.3 and 47.8% with an atriopulmonary connection (APC) and compared them with 19 controls of similar age, race, gender and BMI profile without known chronic disease. Means of biomarker values and their 95% confidence intervals were calculated for each group and results for both were evaluated for significance using the Wilcoxon tests. Functional status of Fontan patients was assessed by 6-minute walk distance (6MWD).
Results: Fontan patients had mean 6MWD of 456.1 ± 58.5 m, and mean baseline SpO2 of 91.6 ± 4.9%. Mean time from Fontan was 19.9 ± 9.5 yr. Despite being medically stable, a variety of systemic biomarkers were dysregulated as compared to controls (Table 1). Inflammatory marker IL-1a, VEGF, NT-pro-ANP and cTroponin-1 were differentially regulated in patients with APC versus total cavopulmonary connection (TCPC).
Conclusions: Functionally stable Fontan patients have dysregulation of multiple systemic pathways in comparison to healthy controls, as reflected in the assayed biomarkers. Differences in the type of dysregulated biomarkers between the APC and TCPC group suggest differences in the pathophysiology within Fontan patients.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Redefining the “F” Word
Abstract Category: 9. Congenital Heart Disease: Adult
Presentation Number: 1270-009
- 2017 American College of Cardiology Foundation