Author + information
- Rahat Muslema,b,
- Kadir Caliskana,b,
- Sakir Akina,b,
- Dennis A. Hesselinka,b,
- Glen J.R. Withmana,b,
- Ryan Tedforda,b,
- Ad J.J.C. Bogersa,b,
- Olivier Manintvelda,b and
- Stuart Russella,b
Background: Data on the consequence of acute kidney injury (AKI) after continuous-flow left ventricle assist devices (LVAD) are scarce and inconsistent. In the current study, the incidence and predictors of AKI and its impact on mortality and renal function in the first year after LVAD implantation was evaluated.
Methods: A retrospective multicentre cohort study was conducted, including all patients (age ≥18) undergoing LVAD implantation (HeartMate III or HVAD). The definition proposed by the Kidney Disease Improving Global Outcome criteria (KDIGO) was used to define AKI.
Results: Overall, 241 patients (mean age 52.4 std. 12.9 years, 76% male, 64% BTT) were included. AKI criteria was met in 169 (70%) LVAD patients, of which 109 (45%) had AKI stage I, 22 (9%) stage II and 38 (16%) stage III. The need for inotropic support and pre-existent severe kidney failure (eGFR <30 ml/min/1.73 m2) were independently associated with the development of AKI and subsequent higher AKI stages. One-year mortality rates in patients without AKI, AKI stages I, II and III were 18.7%, 26.4%, 23%,51%, respectively (log-rank p=0.001, Figure 1). In multivariable analysis AKI stages ≥ II were independently associated with a worse renal function at 1 year (p<0.01).
Conclusions: AKI is highly frequent after LVAD implantation. More severe AKI stages are associated with impaired renal function and subsequent higher mortality rates in the first year after LVAD implantation.
Moderated Poster Contributions
Heart Failure and Cardiomyopathies Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 1:00 p.m.-1:10 p.m.
Session Title: Advanced Therapies = Advanced Trouble: VAD and Transplant Challenges
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1318M-07
- 2017 American College of Cardiology Foundation