Author + information
Background: Majority of patients with chronic obstructive pulmonary disease (COPD) simultaneously suffer from often-unrecognized chronic heart failure (HF). Their timely identification is challenging as both conditions share similar clinical presentations. We performed this meta-analysis to compare plasma BNP levels and systolic dysfunction in subjects with chronic obstructive pulmonary disease (COPD).
Methods: We calculated pooled odds ratios (OR) and 95% confidence intervals (CI) using random-effects models from eight randomized and non randomized studies that compared plasma BNP levels in COPD patients to predict the chances of having cardiovascular diseases. Transthoracic echocardiographic examinations were also performed in the hospitalized subjects.
Results: Of the 996 total subjects, the proportion of COPD subjects with left ventricular dysfunction had significant association with elevated BNP or NT-proBNP (95% CI 1.40-2.43, p=0.02). There was also a statistically significant association between a raised BNP and NT-proBNP measurement and increased mortality in COPD patients (95% CI 2.97-4.63, p=0.04).
Conclusions: Our study confirms that BNP can help physicians in identifying heart failure in patients suffering from an acute exacerbation of COPD or stable COPD. In summary, it appears that in COPD patients there may be a link between an elevated level of BNP or NT-proBNP and increased cardiovascular diseases including mortality.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Heart Failure and Cardiomyopathies: Is Heart Failure With a Normal EF for Real?
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1121-247
- 2017 American College of Cardiology Foundation