Author + information
- Ana Elisa Marabini Martinellia,b,
- Raul C. Maranhaoa,b,
- Priscila O. Carvalhoa,b,
- Milena N.C. Curiatia,b,
- Thauany M. Tavonia,b,
- Fatima R. Freitasa,b and
- Antonio Barrettoa,b
Background: HDL has several functions beyond its role in reverse transport of cholesterol, such as anti-inflammatory, anti-oxidative, anti-apoptotic and vasodilator functions, among others. HDL-cholesterol is unsufficient to fully evaluate HDL protective potential. Lipid transfers of cholesterol and other lipids to HDL, as assayed in vitro has been associated to disease, metabolic alterations, dietary and physical activity status. The aim was to investigate plasma lipid, inflammatory and HDL-related parameters in HF patients classified as to disease severity.
Methods: Forty-eight HF patients (ejection fraction ≤40%), 25 in class NYHA I/II (HF-I/II) and 23 in NYHA III/IV(HFIII/IV); and 50 non-HF gender/age matched patients had plasma collected for biochemical analysis. Transfers of radioactive lipids from a donor artificial emulsion to HDL were determined in vitro.
Results: Total, LDL and HDL cholesterol and triglycerides were equal in HF-I/II, HF-III/IV and non-HF, but apo A-I and apo B were lower in both HF groups compared to non-HF. Transfer of esterified and unesterified cholesterol, triglycerides and phospholipids (in %) were lower in HF-III/IV than in non-HF (HF-III/IV: 5.4±1.8, 6.3±2.1, 19.1±2.5, 6.3±2.1; non-HF: 6.2±0.8, 7.3±1.5, 20.2±1.4,7.4±1.5; respectively, p<0.05). OxLDL was lower in HF-III/IV than in non-HF (p≤0.001). CETP mass was lower in HF-III/IV than in HF-I/II. LCAT activity was lower in HF than non-HF subjects. Transfer of lipids to HDL, apo A-I, apo B, oxLDL and LCAT were negatively correlated with IL-6 and BNP levels.
Conclusions: Lower LDL-ox and apo B were associated not only with HF but also with the severity of the disease, whereas LDL and HDL cholesterol were lower in HF but not different towards disease severity. Lipid transfers were lower in HF than in non-HF and negatively correlated with BNP level, the disease severity marker. The study findings highlight the extensive involvement of the plasma lipids and HDL metabolism with HF presence and severity and the importance of elucidating causative mechanisms related with lipid metabolism disfunction.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Making Progress in Understanding Heart Failure
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1123-274
- 2017 American College of Cardiology Foundation