Author + information
- Emmanuel Akintoye,
- Karim Mahmoud,
- Jarrett Weinberger and
- Luis Afonso
Background: We sought to evaluate the impact of left ventricular mass index (LVMI) and other hemodynamic and demographic variables on incident heart failure.
Methods: This study was conducted using the prospectively-collected database of the Multi-ethnic Study of Atherosclerosis. LVMI and other hemodynamic (measured by pulse wave and MRI) and demographic variables were combined in a multivariate Cox model to predict incident heart failure (of any type) over 10 year period. HFpEF and HFrEF were considered as secondary endpoints. Estimates are reported as hazard ratio [95% CI]
Results: 4627 participants with mean (SD) age of 62 (10) who had non-missing values for the 10-year follow up period were included in this study. LVMI predicted incident heart failure (4th vs 1st quartile: 4.7 [1.8, 11]) (fig 1). The magnitude of the association was far greater for HFrEF (11 [2.4, 52]) than HFpEF (3.6 [1.3, 10]). Other independent predictors of HF include age (2.0 [1.6, 2.6], per 10 year increase), gender (1.9 [1.2, 3.1]), smoking (2.0 [1.3, 3.3]), exercise (0.99 [0.98, 1.0]), hypertension (1.7 [1.0, 2.7]), diabetes (1.8 [1.2, 2.7]), total vascular impedance (1.3 [1.1, 1.7]), and small artery elastic index (0.62 [0.44, 0.87]) (Table 1). However, there was varying impact of these predictors on HFrEF compared to HFpEF.
Conclusions: We identified independent predictors of 10-year incident heart failure. In addition, we showed that the magnitude of association varies between HFrEF and HFpEF
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Making Progress in Understanding Heart Failure
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1123-281
- 2017 American College of Cardiology Foundation