Author + information
- Jeffrey S. Bergera,b,
- Eric Petersona,b,
- François Lalibertéa,b,
- Guillaume Germaina,b,
- Dominique Lejeunea,b,
- Jeffrey Scheina,b,
- Patrick Lefebvrea,b,
- Qi Zhaoa,b and
- Matthew Weira,b
Background: Patients diagnosed with heart failure (HF) have a higher risk of developing stroke than non-HF patients. Few studies have evaluated the risk of stroke in HF patients without atrial fibrillation (AF).
Objective: To quantify the incremental risk of ischemic stroke over time among patients newly diagnosed with HF and without history of AF.
Methods: A retrospective matched cohort study was conducted using the Truven Health Analytics MarketScan Databases (01/2010-04/2015). Adult HF patients with ≥18 months of enrollment prior to the index HF (baseline period) were matched 1:1 with non-HF patients based on a propensity score method. Patients whose stroke evaluation was conducted within 14 days of the index HF and patients with AF at baseline were excluded. Ischemic stroke was defined as a primary diagnosis during a hospitalization. Kaplan-Meier rates for strokes were evaluated by 6 month intervals (e.g., 0-6 months, 6-12 months).
Results: A total of 52,005 patients were included in each cohort. Both cohorts were well balanced and had similar mean observation period (471 vs 451 days). Although risk of stroke decreased over time, it was significantly higher during the first 3 years (especially high the first 12 months) for HF patients (Figure 1).
Conclusions: HF patients without prior AF had a higher risk of stroke compared to non-HF patients. The overall risk decreases over time and higher risks were observed in the first 6-12 months. It took over 3 years to observe a similar stroke-risk level as non-HF patients
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Making Progress in Understanding Heart Failure
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1123-283
- 2017 American College of Cardiology Foundation