Author + information
- Satu Vaara,
- Perttu Salo,
- Markus Perola,
- Olavi Parkkonen,
- Marja-Liisa Lokki,
- Aki S. Havulinna,
- Veikko Salomaa,
- Markku Nieminen and
- Juha Sinisalo
Background: A genetic variant on chromosome 1p13.3 (rs656843, C/T) near the DRAM2 gene was identified to have an association with non-ST-elevation myocardial infarction. Our objective was to study, whether rs656843 is additionally associated with other manifestations of atherosclerosis, such as peripheral artery disease (PAD), or with adverse outcomes.
Methods: A cohort of 2,090 consecutive patients with acute coronary syndrome (ACS) who underwent coronary angiography was genotyped and prospectively followed over a median of 5.5 years. The findings concerning PAD were further tested in a general population sample of 21,161 individuals.
Results: In the ACS cohort, rs656843 (C-allele) was significantly associated with a higher incidence of PAD during the follow-up (multivariable adjusted hazard ratio 1.75, 95% confidence interval 1.19-2.59, P=0.005 in Cox regression). Apart from PAD, the risk allele carriers did not clinically differ from non-carriers. In the general population sample, including considerably healthier and younger individuals, the association with incident PAD could not be replicated.
Conclusions: In terms of both genetics and clinical phenotypes, PAD is more heterogeneous than coronary artery disease (CAD). When compared to CAD, only few risk variants for PAD have been revealed. This may explain why the association between rs656843 and PAD could be demonstrated only in a highly selected sample of ACS patients and not in a general population sample.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Traditional and Novel Factors Used to Assess the Risk of, and Used for the Treatment of, Coronary Artery Disease
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1126-335
- 2017 American College of Cardiology Foundation