Author + information
- Georgios Tzanisa,b,
- Maria Bonoua,b,
- Georgios Benetosa,b,
- Smaragda Bilioua,b,
- Stavros Liatisa,b,
- Elias Sanidasa,b,
- Konstantinos Toutouzasa,b,
- John Barbetseasa,b and
- Cardiology Departmenta,b
Background: Diabetes mellitus (DM) is an independent risk factor for major cardiovascular events. The role of vulnerable plaque inflammation seems to play a crucial role. Microwave radiometry (MWR) is a new non-invasive method allowing measurement of the temperature of tissues, thus reflecting inflammation. The aim of this study was to evaluate the relation of DM and coronary artery disease (CAD) with carotid artery inflammation.
Methods: We assessed 65 patients that were referred to our department for diagnostic evaluation of their clinical condition with coronary angiography (CA). We consecutively evaluated 41 DM patients (27 males, 67±9 yrs, 30±5 kg/m2) and we also selectively included a control group of 24 patients (without DM: 16 males, 64±9 yrs, 29±4 Kg/m2), with a 2:1 ratio (DM vs Controls). Patients were also evaluated for the temperature difference (ΔT) along each carotid artery with MWR, and the maximum temperature difference between the 2 carotid arteries (ΔTmax).
Results: Patients with DM presented significantly higher ΔTmax comparing to the control group (0.88±0.32 vs 0.58±0.21 °C, p<0.005). Patient's with CAD also presented higher ΔTmax values comparing to patients with a normal CA (0.93±0.25 vs 0.63±0.38 °C, p<0.003). Patients that finally underwent coronary revascularization presented higher ΔTmax values (0.97±0.23 vs 0.75±0.34 °C, p<0.017) and the subgroup of the CAD patients with multivessel involvement showed a trend for higher ΔTmax values.
Conclusions: Local inflammatory activation of carotid arteries, as assessed by MWR, seems to be higher in DM patients and might correlate with the presence of CAD and the need for revascularization. Further studies should investigate the predictive role of atherosclerotic plaques inflammation.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Traditional and Novel Factors Used to Assess the Risk of, and Used for the Treatment of, Coronary Artery Disease
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1126-336
- 2017 American College of Cardiology Foundation