Author + information
- Yashwant Agrawal,
- Chris Jacob,
- Sourabh Aggarwal,
- Sidakpal Panaich,
- Frank Saltiel,
- Jagadeesh Kalavakunta and
- Vishal Gupta
Background: Vitamin D deficiency (VDD) is a universal disorder, involved in the pathogenesis of coronary artery disease (CAD). The atherosclerotic character of vitamin D deficiency is known to increase cardiovascular events. This study was done to review the impact of VDD on CAD in the US for years 2008 to 2012.
Methods: We used Nationwide Inpatient Sample (NIS) data to extract data for patients who were hospitalized with a primary/secondary diagnosis of CAD as specified by International Classification of Disease (ICD-9) codes 410.00-414.00. VDD was identified by ICD-9 codes 268.0, 268.1, 268.2, and 268.9. NIS data is 20% representative of all hospital data in US. Data was extracted from years 2008 to 2012. Logistic regression models were used to analyze the association between VDD and CAD.
Results: A total of 33,798,064 weighted discharges were identified with primary/secondary diagnosis of CAD of which 227,042 also had VDD. Mean age of CAD patients with and without VDD was 73.5 and 71.2 years, respectively. More females had CAD and VDD when compared to males (55.1% vs. 44.9%). However, for CAD patients without VDD, males were predominant (54.5% vs. 43.5%). When controlling for demographics, diabetes and hypertension; the association between Vitamin D level and CAD was statistically significant (p<0.0001). Estimated odds for having CAD was 1.13 (95% CI: 1.10, 1.16) times greater in patients with VDD. Similarly, estimated odds for a length of stay more than 1 week for CAD was 1.36 (95% CI: 1.30, 1.42; p<0.0001) times greater in patients with VDD. Estimated odds for in-hospital mortality for CAD with VDD was 1.81 (95% CI: 1.69, 1.94; p<0.0001) times greater than for CAD without VDD.
Conclusions: This study attempted to characterize the impact of VDD on CAD. There was statistically significant association of Vitamin D level with CAD. There was statistically significant increased length of stay and in-hospital mortality in patients to have CAD with underlying VDD. This is perhaps the first in-hospital database designed study showing the impact of VDD on CAD. Continued studies are needed to investigate the influence of VDD on CAD, and its possible use as a predictive marker.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Traditional and Novel Factors Used to Assess the Risk of, and Used for the Treatment of, Coronary Artery Disease
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1126-337
- 2017 American College of Cardiology Foundation