Author + information
- Juan Pablo Costabel,
- Santiago Ordoñez,
- Ivan Chillik,
- Eugenio Diaz Romero,
- Victoria Galizia Brito,
- Juan Furmento and
- Marcelo Trivi
Backgroud: It is of vital importance to determinate the prognosis of patients with acute coronary syndrome without ST elevation (NSTEMI). Many risk scores and biomarkers have been studied. GRACE and TIMI scores as well as troponin T have shown to have the best prognosis value. However, it is still not clear which of them is the best method to predict adverse cardiovascular events.
Methods: We carried out a retrospective, single center study on 1011 patients consecutive admitted with diagnosis of NSTEMI. High sensitive troponin T (hsTT) was dosed on admission (hsTT adm) and 3 hours later (hsTT 3h), GRACE and TIMI scores were calculated. We assessed hsTTS adm, hsTTS 3h, delta TTS, GRACE and TIMI scores and the addition of GRACE and hsTTS adm (GhsTT) in terms of performance in predicting adverse events (recurrent angina (RA), acute myocardial infarction (AMI), stroke and death) during hospitalization.
Results: The rate of adverse combined cardiovascular events (MI, RA, stroke and death) during hospitalization was 8.9%. The rate of RA was 4,5%. MI 3,5%, stroke 0,4% and death 1,3%. The area under the ROC curve (AUC) for the prediction of combined events incidence was 0,52 for GRACE score, 0,54 for TIMI score, 0,83 for hsTT adm, 0,80 for hsTT 3h, 0,80 for delta hsTT and 0,79 for GhsTT. The AUC values for the prediction of MI or death were 0, 51 for GRACE score, 0,56 for TIMI score.
Conclusions: High sensitive Troponin T has high predictive value for adverse cardiovascular events such as recurrent angina, myocardial infraction, stroke and death during hospitalization. In our population, hsTT presented a better performance than GRACE and TIMI scores.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Traditional and Novel Factors Used to Assess the Risk of, and Used for the Treatment of, Coronary Artery Disease
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1126-340
- 2017 American College of Cardiology Foundation